CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. In pediatric studies, the incidence of binding antibodies to Nplate at any time was 7.8% (22/282). If you have certain conditions that affect your platelets, your doctor may prescribe Nplate. They may recommend over-the-counter pain relievers and home remedies, if needed. Sorry, we have no data available. It is often used in idiopathic thrombocytopenic purpura (itp). But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) "Product Information. Cough. To learn about other mild side effects, talk with your doctor or pharmacist, or read Nplates medication guide. Overall, Nplate was administered to 114 patients for at least 52 weeks and 53 patients for at least 96 weeks. Children: Fever. Nplate may not be right for you if you have certain medical conditions or other factors that affect your health. Check with your doctor or nurse immediately if any of the following side effects occur while taking romiplostim: Some side effects of romiplostim may occur that usually do not need medical attention. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. eHealthMe is studying from 16,827 Nplate users for its effectiveness, alternative drugs and more. Nplate comes as a powder that your doctor will mix into a solution. If I reach a certain platelet level, can I stop receiving Nplate injections. (With ITP, you have a low level of platelets thats caused by your immune system.). 3. Additionally, 2.5% (7/282) developed neutralizing antibodies to Nplate. Stomach pain or diarrhea. Please contact your doctor or pharmacist. (Platelets help your blood to form clots.) Your doctor may adjust your dosing guide depending on your bodys response to Nplate. (Doctor & assistants say they're not all side effects, even though they occurred at the same time and I thought I saw them listed as such.) Nplate has active ingredients of romiplostim. Patients were evaluated for bone marrow reticulin formation and collagen fibrosis using the modified Bauermeister grading scale. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips . Amgen USA (2008): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This medication is a bispecific BCMA-directed CD3 T-cell engager used to treat some forms of multiple myeloma (MM). The incidence of new binding antibody development was 3.8% (7/184) to romiplostim and 2.2% (4/184) were positive for binding, non-neutralizing antibodies to TPO; two patients were positive for binding antibodies to both romiplostim and TPO. Different individuals may respond to medication in different ways. If you experience side effects when taking Nplate, be sure to tell your doctor. Immune thrombocytopenia (ITP) leads to excessive bleeding. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. What Are Side Effects of Nplate? Learn about the different types of bleeding disorders and how theyre. Nplate 250mcg should be used only in patients with ITP whose degree of thrombocytopenia and clinical condition increases the risk for bleeding. On the 18th and 19th my whole upper lymph system hurt more severely, burning pain in my spine and sternum. (Platelets help your blood to form clots. Nplate (romiplostim) sales increased 5% year-over-year for the third quarter, primarily driven by 12% volume growth, partially offset by unfavorable changes to estimated sales deductions. The most common side effects of Nplate in adults include: The most common side effects of Nplate in children 1 year of age and older include: People who take Nplate may have an increased risk of developing new or worsening changes in the bone marrow called "increased reticulin". The safety profile of Nplate was similar across patients, regardless of ITP duration. Learn about the common symptoms of immune thrombocytopenic purpura (ITP) and how they are sometimes mistaken for other conditions. The most common side effects of Nplate in adults include: headache tingling or numbness in hands and feet joint pain bronchitis dizziness inflammation of the sinuses ( sinusitis) trouble sleeping vomiting muscle tenderness or weakness diarrhea pain in the arms and legs upper respiratory tract infection stomach (abdomen) pain cough shoulder pain The lowest GoodRx price for the most common version of Nplate is around $17,519.92, 37% off the average retail price of $27,972.76. Anemia Symptoms and Signs, Types, Treatment and Causes. Rash (15%) Upper abdominal pain (14%) 1-10% (Adults) Should pain (8%) Dyspepsia (7%) Paresthesia (6%) Thrombocytosis (2%) >5% Bronchitis Sinusitis Vomiting Arthralgia Myalgia Headache Dizziness. Adults: Dizziness or headache. By working in this way, Nplate helps to offset your low level of platelets. muscle pain. The safety profile of Nplate If you have serious side effects from Nplate, call your doctor right away. While Nplate contains the active drug romiplostim, Promacta contains the active drug eltrombopag. This medicine is used to treat low platelets caused by chronic idiopathic thrombocytopenic purpura (ITP) or a bone marrow syndrome caused by radiation sickness. Then, theyll give the solution to you as an injection. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. See below for a comprehensive list of adverse effects. Unlike romiplostim, eltrombopag isnt a biologic drug. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Serious side effects from Nplate can occur, but they arent common. If you have questions about whether Nplate may cure your condition, talk with your doctor. drugs a-z list Studies suggest that Nplate is safe to take long term. do flies lay eggs when they die. This is important, as some drugs can interfere with Nplate. However, before starting Nplate, ask your doctor or pharmacist if its safe for you to drink alcohol while taking this drug. Looking for ways to naturally increase your platelet count? So, if your bone marrow was harmed by radiation, you may have a low level of platelets. O 0, 2. The study uses data from the FDA. 12 Medicines That Could Help. Learn about eight types of ITP treatment, how each one works, potential side effects, and. These and other considerations to discuss with your doctor are described below. All rights reserved. Side Effects What are the side effects of Nplate (Romiplostim)?. The users guide to prescription drugs and supplements: Finding the right medication is important Let RateADrug help. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals redness of the skin trouble swallowing Some side effects may occur that usually do not need medical attention. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. Mild side effects of Nplate that have been reported include: dizziness* pain in your joints and muscles* trouble sleeping belly pain upset stomach tingling, burning, or numbness of your skin. The most common side effects of Nplate in adults include: headache joint pain dizziness trouble sleeping muscle tenderness or weakness pain in arms and legs stomach (abdomen) pain shoulder pain indigestion tingling or numbness in hands and feet bronchitis inflammation of the sinuses (sinusitis) vomiting diarrhea upper respiratory tract infection If you need to take Nplate over a long period of time and youre concerned about long-term side effects, talk with your doctor or pharmacist. They can also suggest ways to help reduce side effects. All information is observation-only. Nplate Patient Information is supplied by Cerner Multum, Inc. and Nplate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. These side effects may go away during treatment as your body adjusts to the medicine. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Other side effects include: dyspepsia, paresthesia, and shoulder pain. Patients or physicians may enroll by calling 1-800-77-AMGEN (1-800-772-6436) General side effects from romiplostim (Nplate) Headache; Joint pain [arthralgia] Dizziness . ), Nplate is a prescription drug thats used in adults and some children with immune thrombocytopenia (ITP) that hasnt improved with other treatments. "Majority of reports" connected to all of. Be sure to follow your doctors advice about your dosage. Table 3. But, Nplate and Promacta also have other unique uses. You can also visit the Nplate manufacturers website to see if they have support options. 10 Signs Your ITP Treatment Isnt Working, Complementary Therapies for Immune Thrombocytopenia Purpura, Blood Diseases: White and Red Blood Cells, Platelets and Plasma, How to Naturally Increase Your Platelet Count, Heparin-Induced Thrombocytopenia: Symptoms, Treatment, Outlook, and More, tingling, burning, or numbness of your skin, immunoglobulins (immune system proteins) such as. Healthline Media does not provide medical advice, diagnosis, or treatment. These changes may improve if you stop taking Nplate. For this use, the drug can be given to adults and children, including newborns. We've detected that you're using an ad content blocking browser plug-in or feature. Rate Nplate to receive MedCheck, Discover best treatments based on user reviews of side effects, efficacy, health benefits, uses, safety and medical advice. If youre taking Nplate for immune thrombocytopenia (ITP), your doctor will give you Nplate injections once every week. All rights reserved. diarrhea. Select a condition to view a list of medication options. Examples of possible ITP treatments include: Below are answers to some common questions about taking Nplate. It attaches to the TPO receptor (binding site) on a type of bone marrow cell called a megakaryocyte. The safety profile of Nplate The following side effects have been reported by at least 1% of people taking Nplate (Romiplostim). Pain in arms or legs. Our website services, content, and products are for informational purposes only. You may report them to the FDA. Among 291 adult patients with ITP who received Nplate in the single-arm extension study, the incidence rates of the adverse reactions occurred in a pattern similar to those reported in the placebo-controlled clinical studies. What is Nplate used for? Factors to consider include those in the list below. Nplates mechanism of action mimics how your bodys natural thrombopoietin works. Learn more. If you receive too much Nplate, your doctor will stop Nplate injections and check your platelet level. Heres a list of articles that you might find helpful: Additionally, some questions to ask your doctor about Nplate may include: In studies, 1 in 3 people who took Nplate for immune thrombocytopenia (ITP) maintained a stable platelet level after stopping treatment. Costs of prescription drugs can vary depending on many factors. Patients were screened for immunogenicity to romiplostim using a BIAcore-based biosensor immunoassay. Of the seven patients with positive binding antibodies to romiplostim, one patient (0.5%; 1/184) was positive for neutralizing antibodies to romiplostim only. They can talk with you about the risks and benefits of Nplate treatment. It does this by attaching to certain cells in your bone marrow. If you have a bleeding disorder called immune thrombocytopenia (ITP) your doctor may prescribe Nplate. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. These side effects may go away during treatment as your body adjusts to the medicine. Nplate is a thrombopoietic receptor agonist (TPO-RA). joint pain, muscle weakness or tenderness; numbness or tingling in your hands or feet; stomach pain, indigestion, nausea, vomiting, diarrhea; cough, wheezing, chest tightness, trouble breathing; Progression of Myelodysplastic Syndromes [see, Thrombotic/Thromboembolic Complications [see, Hypersensitivity reactions including angioedema and anaphylaxis. Along with its needed effects, romiplostim (the active ingredient contained in Nplate) may cause some unwanted effects. Based on cohort assignment at time of study enrollment, patients were evaluated for bone marrow reticulin and collagen at year 1 (cohort 1), year 2 (cohort 2), or year 3 (cohort 3) in comparison to the baseline bone marrow at start of the trial. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. But Nplate isnt one of them. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Also describe any vitamins, herbs, or supplements you use. Learn about treatment options. Blood cell disorders impair the formation and function of red blood cells, white blood cells, or platelets. The redirected T-cells kill MM cells via various mechanisms. children ages 1 year and older whove had ITP for at least 6 months that didnt improve with other ITP therapies (listed above). And they didnt worsen over time. Some of those reactions have included skin inflammation and rash. Administer . With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. The data described below reflect Nplate exposure to 271 adult patients with ITP, aged 18 to 88, of whom 62% were female. Talk with your doctor about your health history before you take Nplate. Common side effects of Nplate include: headache, joint or muscle pain, dizziness, heartburn, abdominal pain, stomach upset, tingling or numbness in hands or feet, trouble sleeping (insomnia), or pain in your arms/legs/ shoulder Dosage for Nplate The initial dose for Nplate is 1 mcg/kg based on actual body weight. 3 DOSAGE FORMS AND STRENGTHS For injection: 125 mcg, 250 mcg or 500 mcg of Nplate as a sterile, lyophilized, solid white powder in single-dose vials. (With ITP, you have a low level of platelets thats caused by your immune system. Nplate is not available in a biosimilar form. Ads provide a critical source of revenue to the continued operation of Silicon Investor. Your doctor or pharmacist can tell you about any interactions these items may cause with Nplate. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. 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