For a full list of Inside Rx program terms see full terms or call 800-722-8979. Repatha Pushtronex is a clear to opalescent, colorless to pale yellow solution. However, under these conditions, Repatha Pushtronex must be used within 30 days. *Subject to eligibility criteria. Related Search Interaction with other medicinal products and other forms of interaction, All rights reserved Pillintrip.com 2018. Follow any state or local laws about throwing away used needles and syringes. Patients whose sera tested positive for binding antibodies were further evaluated for neutralizing antibodies; none of the patients tested positive for neutralizing antibodies. Repatha Pushtronex, Repatha Sureclick, Repatha It is used to lower cholesterol. Prior to use, allow Repatha Pushtronex to warm to room temperature for at least 30 minutes. Throw away the used autoinjector and orange needle cap. The mean age was 57 years (range: 18 to 80 years), 29% were older than 65 years, 49% women, 85% White, 5% Black, 9% Asian, and 5% Hispanic. This program is administered by Medical Security Card Company, LLC, Tucson, AZ. The proportions of patients who discontinued treatment due to local injection site reactions in Repatha Pushtronex-treated patients and placebo-treated patients were 0.1% and 0%, respectively. The Repatha Pushtronex system consists of a single-use, battery-powered infusor and a prefilled cartridge containing a 420-mg dose of evolocumab. The medication system used was a sample, so I just need to code for the application of the system. For this purpose, Repatha is used with a healthy diet and may be used with other LDL-lowering drugs or on its own. What is the most important information I should know about Repatha Pushtronex? Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Adverse reactions reported in at least 3% of Repatha Pushtronex-treated patients, and more frequently than in placebo-treated patients in Study 2, are shown in Table 1. The dosage is based on your medical condition. Angioplasty & Stent Procedure. You will receive notice when necessary. Related Videos. Keep out of the reach of children and pets.Store in a refrigerator or at room temperature between 20 and 25 degrees C (68 and 77 degrees F).Refrigeration (preferred): Store it in the refrigerator. Healthcare practitioners should use their professional judgment in using the information provided. This site is intended for U.S. residents only. Repatha Pushtronex is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). Ask your health care provider how much you should exercise. * Call 1-844-REPATHA ( 1-844-737-2842) SHARE Hours of operation: 8 AM-11 PM ET It is used with lifestyle changes, like diet and exercise. Do not co-administer Repatha Pushtronex with other injectable drugs at the same injection site. Repatha Pushtronex is indicated as an adjunct to diet and other LDL-lowering therapies (e.g., statins, ezetimibe, LDL apheresis) for the treatment of patients with homozygous familial hypercholesterolemia (HoFH) who require additional lowering of LDL-C. REPATHA PUSHTRONEX Information En Espaol What is this medication? Approved Use Repatha is an injectable prescription medicine used: in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart surgery. Repatha is available in prefilled syringes, SureClick autoinjectors, and cartridges for use with the Pushtronex system. These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries. Use REPATHA exactly as your healthcare provider tells you or your child to use it. If you do not have a sharps container, call your pharmacist or health care provider to get one.This medicine comes with INSTRUCTIONS FOR USE. Watch how to store, use, and discard the Repatha Pushtronex system (single-dose on-body infusor with prefilled cartridge). Do not use if the medicine has changed colors or has particles in it. 1A. Tell your health care provider if your symptoms do not start to get better or if they get worse.You may need blood work while you are taking this drug.Do not wear the on-body infuser during an MRI.Taking this drug is only part of a total heart healthy program. TO90% OF PEOPLE The most common injection site reactions were erythema, pain, and bruising. Use a different place each time you give an injection. Health First Commercial Plans, Inc. is doing business under the name of Health First Health Plans. Repatha is a prescription medicine used to treat the symptoms of reduce the risk of myocardial infarction, stroke and coronary revascularization and Primary Hyperlipidemia. The recommended subcutaneous dosage of Repatha Pushtronex in patients with HoFH is 420 mg once monthly. What is Repatha and how is it used? Read the information carefully. Repatha.com is a Medicine website . Do not heat a syringe or injection device. Evolocumab may also be used for purposes not listed in this medication guide. Do not freeze. Repatha Pushtronex is a human IgG monoclonal antibody which targets PCSK9 (proprotein convertase subtilisin/kexin type 9). 3A. Adverse Reactions in Patients with Primary Hyperlipidemia and in Patients with Heterozygous Familial Hypercholesterolemia. Evolocumab is not approved for use by anyone younger than 13 years old. More. It works by helping the liver reduce levels of "bad" cholesterol circulating in your blood. 2022 Amgen Inc., All rights reserved. Also tell them if you smoke, drink alcohol, or use illegal drugs. What side effects may I notice from receiving this medication? Prescription Settings brand sureclick Adverse Reactions in Seven Pooled 12-Week Controlled Trials. Enter your ZIP Code and Prescribed Quantity. Repatha is given under the skin (subcutaneously), every 2 weeks or 1 time each month. Individuals with familial hypercholesterolemia often may have "gain of function" mutations in the PCSK9 molecules in their body, resulting in increased LDL-C plasma levels and a consequent cardiovascular risk. Because the formation of complexes between LDL receptor and PCSK9 are prevented, the internalized LDL receptors are less likely to be degrated by lysosomes and may recycle to the surface of the cell to serve their function of removing LDL from the blood. these forms of Repatha may not be safe for you to use. Musculoskeletal adverse reactions were reported in 14.3% of Repatha Pushtronex-treated patients and 12.8% of placebo-treated patients. Total bioavailability from subcutaneous injection was 82% in cynomolgus monkeys. The most common allergic reactions were rash (1.0% versus 0.5% for Repatha Pushtronex and placebo, respectively), eczema (0.4% versus 0.2%), erythema (0.4% versus 0.2%), and urticaria (0.4% versus 0.1%). PCSK9 inhibitors. journey with your doctor. Remove 1 Repatha SureClick autoinjector from the package. Evolocumab may also be used for purposes not listed in this medication guide. Visit, in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of heart. Inside Rx cannot be used with any insurance benefit, copay assistance programs, or by persons covered by state-funded or federal-funded programs such as Medicare, Medicaid, or Tricare for purchases of certain medications, even if processed outside the benefit as an uninsured (cash-paying) patient. Do not use an injection device that has been dropped onto a hard surface, even if you cannot see a break in it. Talk to your health care provider about what to do if you miss a dose. READ MORE PATIENT PRODUCT INFORMATION PRESCRIBING INFORMATION INSTRUCTIONS FOR USE IMPORTANT SAFETY INFORMATION APPROVED USE EN ESPAOL FOR HEALTHCARE PROFESSIONALS INSIDE RX IS NOT INSURANCE. Throw away any evolocumab that has been frozen. Adverse Reactions in a 52-Week Controlled Trial. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Ask your doctor or pharmacist if you have questions, or call the manufacturer at 1-844-737-2842. Repatha Pushtronex is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (CVD), who require additional lowering of low density lipoprotein cholesterol (LDL-C). Repatha is a prescription drug used to lower cholesterol and help prevent certain heart-related problems. Dosage Settings Brand Solution Cartridge 3.5ml of 420mg/3.5ml 1 Cartridge Set Your Dosage Make sure your dosage values are correct! Use the medicine within 30 days if it is kept at room temperature. Evolocumab is also used by people who have . Use the medicine exactly as directed. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. We work directly with manufacturers and pharmacies to find you lower prices on thousands of prescription medications. To administer the 420 mg dose, give 3 Repatha Pushtronex injections consecutively within 30 minutes. There are specific as well as general uses of a drug or medicine. Serious hypersensitivity to Repatha Pushtronex or any component of the formulation. Drug information is sourced fromGSDD (Gold Standard Drug Database )provided by Elsevier. Keep taking it unless your health care provider tells you to stop.It is important that you put your used needles and syringes in a special sharps container. Watch these overview videos to learn more about each dosing option and the support available to you. Repatha Pushtronex showed non-linear, dose-dependent clearance in healthy volunteers; clearance decreased with increasing dose. By declining you will be logged out of your account. The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice. It is used alone or with other medicines. Always consult to a doctor or pharmacist before using pills or medicines. Order by phone? Adverse reactions reported in at least 1% of Repatha Pushtronex-treated patients, and more frequently than in placebo-treated patients, are shown in Table 2. Follow state or local laws about how to dispose of this container. Sign In . They. Call your pharmacist for new medicine. It is used with lifestyle changes, like diet and exercise. Pricing shown online or via the Inside Rx app are subject to change in real time. Repatha Pushtronex is the second PCSK9 inhibitor on the market, first being alirocumab. The following adverse reactions are also discussed in other sections of the label: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. Our Terms and Conditions and Privacy Policy have recently been updated. . It is not known whether Repatha Pushtronex will lower the risk of stroke, heart attack, or other heart complications in people with high cholesterol. Use a puncture-proof "sharps" container. Learn more about price differences between brand and generic drugs. 3 Inject. Manufacturer Coupons and Offers Available. There was no evidence that the presence of anti-drug binding antibodies impacted the pharmacokinetic profile, clinical response, or safety of Repatha Pushtronex, but the long-term consequences of continuing Repatha Pushtronex treatment in the presence of anti-drug binding antibodies are unknown. Once assembled, the patient adheres the device to the skin of the abdomen, thigh, or upper arm and presses a button to begin the subcutaneous injection; infusion of the dose takes about 9 minutes. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The effect of Repatha Pushtronex on cardiovascular morbidity and mortality has not been determined. Twenty years of experience as a process development or product quality team leader for AMG 114, denosumab (Prolia and XGEVA), evolocumab (Repatha Sureclick and Pushtronex), axicabtagene . In seven pooled 12-week, double-blind, randomized, placebo-controlled trials, 993 patients received 140 mg of Repatha Pushtronex subcutaneously every 2 weeks and 1059 patients received 420 mg of Repatha Pushtronex subcutaneously monthly. Translations in context of "de Evolocumab" in Spanish-English from Reverso Context: No se ha evaluado el potencial mutagnico de evolocumab. *By signing up I am agreeing to receive price drop alert emails. #1 Is code 96377 the correct code for application of the Repatha Pushtronex System. What should I watch for while using this medication? Evolocumab works by helping the liver reduce levels of "bad" cholesterol (low-density lipoprotein, or LDL) circulating in your blood. Other drugs may affect evolocumab, including prescription and over-the-counter medicines, vitamins, and herbal products. The exact mechanism of the binding has not been published, however the precursor molecule, mAb1, is indicative of the interaction. Sign up or log in to your free WellRx account to gain access to this and other tools to help make managing your medications and wellness easier. You may report side effects to FDA at 1-800-FDA-1088. How it works. Stop taking Repatha and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms. What is REPATHA PUSHTRONEX SYSTEM? There are no known significant interactions. All rights reserved. Download the App Free. You must generally use network pharmacies to use your prescription drug benefit. The INSIDE RX mark is owned by Express Scripts Strategic Development, Inc. Additional terms regarding the prescription drug information on this site, which is provided by Cerner Multum, Inc.: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (Cerner) is accurate, up-to-date, and complete, but no guarantee is made to that effect. The most common adverse reactions that occurred at a rate greater than placebo were back pain (3.2% versus 2.9% for Repatha Pushtronex and placebo, respectively), arthralgia (2.3% versus 2.2%), and myalgia (2.0% versus 1.8%). The day supply is based upon the average dispensing patterns for the specific drug and strength. UP Repatha is the poster child for waste. You will need to wear the device for about 9 minutes to get the full dose. Avoid exposure to extreme heat.To get rid of medicines that are no longer needed or have expired: -Take the medicine to a medicine take-back program. See how Repatha works
The device adheres to the body during administration. While wearing the on-body infusor, you may perform moderate activities such as walking, bending, or reaching. All trademarks are the property of their respective owners. Help. Translations in context of "prellenados por" in Spanish-English from Reverso Context: Hay otras opciones que fueron prellenados por la herramienta de lnea de comandos de exp cuando el proyecto fue creado. The volume of packaging for two injections is over twice the volume for the equivalent dosing of Praluent. Do not shake this medicine. DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. discussion guides below to help you share your heart health Repatha Pushtronex may also be used for purposes not listed in this medication guide. After 12 weeks, your If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. In patients with HoFH, measure LDL-C levels 4 to 8 weeks after starting Repatha Pushtronex, since response to therapy will depend on the degree of LDL-receptor function. For a complete list of participating pharmacies, see pharmacies. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. Attention! 4 Finish. CHEMICAL NAME This list may not describe all possible interactions. Pushtronex System Single-dose on-body infusor with prefilled cartridge 5-minute at-home self-injection with hands-free device Lights and sounds when you start and finish your dose Hidden needle Can inject into your stomach or thigh, or inject into your arm if assisted Documentation of allergenic cross-reactivity for PCSK9 inhibitors is limited. Do not put them in a trash can. Avoid smoking. The lowest GoodRx price for the most common version of Repatha is around $512.90, 14% off the average retail price of $598.12. The Pushtronex on-body infusor is a special device placed on the skin that delivers your evolocumab dose slowly. The mean and median exposure durations of Repatha Pushtronex in this pool of eight trials were 20 weeks and 12 weeks, respectively. Evolocumab is injected under the skin. If an every 2 week or once monthly dose is missed, instruct the patient to: See also:What is the most important information I should know about Repatha Pushtronex? This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Take the medicine out of the refrigerator and let it reach room temperature for 30 to 45 minutes before injecting your dose. Follow your doctor's instructions very closely. Administer Repatha Pushtronex as soon as possible if there are more than 7 days until the next scheduled dose, or. Repatha Pushtronex is a PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures. Do not use Repatha if you are allergic to evolocumab or to any of the ingredients in Repatha. Chart note states: Medication: Repatha Pushtronex system 420mg/3.5ml placed on abdomen- right side and infused over 9 minutes. Evolocumab is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). Ask your pharmacist for directions on how to use this medicine. Dropping an injection device can cause it to break. 2 If patients require assistance, they can enroll in the Repatha Ready program, where nurse support is available by phone or video conference. What are the possible side effects of Repatha? Get emergency medical help if you have signs of an allergic reaction: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat. Your doctor will prescribe the type and dose that is right for you. An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. Repatha may be used alone or with other medications. Evolocumab is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). The mAb1 molecule binds on the catalytic site of PCSK9 next to the binding site for the LDL receptor and creates hydrogen bonds and hydrophobic interactions, resulting in the steric inhibition of binding between PCSK9 and the LDL receptor. Print free coupons for repatha sureclick and find the best deal on your prescription medications today. Avoid alcohol. The adverse reactions described below are from a pool of the 52-week trial (Study 2) and seven 12-week trials. For people who have high levels of LDL, it is used along with a proper diet, alone or other LDL-lowering treatments (such as "statin" drugs, ezetimibe, LDL apheresis). Cerners drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve end-users viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. It is used in some people to lower the chance of heart attack, stroke, and certain heart procedures. It is approved for both homozygous and heterozygous familial cholesterolemia as an adjunct to other first-line therapies. Call your doctor for medical advice about side effects. Repatha comes as a single-use (1 time) prefilled autoinjector (SureClick autoinjector), as a single-use prefilled syringe or as a single-use Pushtronex system (on-body infusor with prefilled . Repatha Pushtronex is also used in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). It can also be used to treat the particular symptom of the disease. Repatha Pushtronex is used together with a low-fat diet and other cholesterol-lowering medications in people with homozygous or heterozygous familial hypercholesterolemia . If it is stored at room temperature, throw away any unused medicine after 30 days or after it expires, whichever is first.Protect from light. QTY 3.5 420 MG/3.5 WEAR INJCT Near 77381, Allergic Reactions (Skin Rash, Itching Or Hives; Swelling Of The Face, Lips, Or Tongue), High Blood Sugar (Increased Hunger, Thirst, Or Urination; Unusually Weak Or Tired, Blurry Vision), Infection (Fever, Chills, Cough, Sore Throat, Pain, Or Trouble Passing Urine), Pain, Redness, Or Irritation At Site Where Injected. According to the drug's manufacturer, Repatha's list price . Patients used the Pushtronex system or 3 autoinjectors for the once-monthly regimen. *Average and up to savings percentages are based on all discounted prescriptions that were run through the WellRx program in 2020. You are encouraged to report negative side effects of prescription drugs to the FDA. Repatha can cause serious side effects including, serious allergic reactions. Prevention of cardiovascular events in patients with established cardiovascular disease: To reduce the risk of MI, stroke, and coronary revascularization in adults with established cardiovascular disease. Side effects that you should report to your doctor or health care provider as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care provider if they continue or are bothersome): This list may not describe all possible side effects. Follow all directions on your prescription label and read all medication guides or instruction sheets. EVOLOCUMAB (e voe LOK ue mab) treats high cholesterol. Tell your doctor about all your current medicines and any medicine you start or stop using. 4A. Evolocumab is also used by people who have heart disease to help prevent heart attacks and strokes.